Wedd Research Group

 

Wedd Group Photo

Front row: Sam, Laura, Xiao. Middle row: Giles, Ashwinie, Chathuri, Tony. Back row: Sean, Nineveh, Reza, Tessa

 

Welcome to the Xiao/Wedd Research Group website. We are from the School of Chemistry at the University of Melbourne and are located in the Bio21 Molecular Science and Biotechnology Institute. We are interested in the roles of various transition metals, including Cu, Fe and Zn in catalysis and biology. We use a multi-disciplinary approach spanning synthetic inorganic chemistry, physical chemistry, protein biochemistry and microbiology. Please use the navigation menu above to find out more about us.

We welcome inquiries from prospective Honours and PhD students and post-doctoral fellows. Please click here for more information about opportunities within the group.

 
 

Recent Group News

  • October 2016

    PhD student Gilles Lekeux from the University of Liege, Belgium has been visiting us for two months. He is investigating the way that zinc binds to N- and C-termini of certain plant zinc transporters. This work will be integrated with his complementation experiments in the plants.

    Sam Graf and Peitong Li have now completed third year research projects in our laboratory. Thanks to Tessa, Chathuri and Ashwinie for helping them have a fruitful time.

    Ashwinie Ukuwela won the Poster Prize at the Copper 10 Conference in Sorrento, Italy from Sept 25-30, 2016. It was awarded for the quality and defence of her poster entitled "Purification and Characterization of Recombinant Copper-Binding Proteins:- Poly-Lysine Tags versus Poly-Histidine Tags". Congratulations, Ashwinie !!

  • September 2016

    Ashwinie Ukuwela and Professor Wedd will attend the Copper 10 Conference in Sorrento, Italy from Sept 25-30, 2016. Ashwinie will present a poster entitled "Purification and Characterization of Recombinant Copper-Binding Proteins:- Poly-Lysine Tags versus Poly-Histidine Tags".

    Professor Wedd will also visit our collaborators Drs Roland Knorr and Rumiana Dimova at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany

  • August 2016

    Ben Spyrou won The Professor Kernot Research Scholarship in Chemistry and also the Stanley Harvey Prize for his MS work in our group during 2016. Congratulations to you, Ben !! The prizes were presented at the Chemistry Awards Ceremony on Aug 4, 2016.

    Tessa Young will attend the EuroBIC 13 Conference in Budapest, Hungary to be held from Aug 28-Sep 6, 2016. Her poster presentation is entitled "The Amyloid Precursor Protein and Copper Ions".

    Reza Todfekr has just arrived to commence a PhD degree with our group. Reza holds a Master of Science degree in Inorganic chemistry from the Iran University of Science and Technology, Tehran, Iran./p>

  • July 2016

    Chathuri Wijekoon won the Young Scientists Oral Presentation Award at the Biometals 2016 Conference held in Dresden, Germany from July 10-15, 2016. Congratulations, Chathuri !! Her presentation was entitled "A Copper Chaperone Protein with an Unusual High-Affinity Cu(II) Binding Site".

  • April 2016

    Chathuri Wijekoon will soon leave to visit the laboratories of Dr. Rumiana Dimova who leads the Biophysics Laboratory within the Department of Theory and Bio-Systems of the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany. She will gain experience with generating so-called giant uni-laminar vesicles as simple mimics of biological cells.

  • March 2016

    Sean Lim has joined us to undertake his Honours degree. Initially, he will work with Chathuri Wijekoon on aspects of CopA chemistry.

  • January 2016

    Our paper entitled "Metal binding to the N-terminal cytoplasmic domain of the PIB ATPase HMA4 is required for metal transport in Arabidopsis" by C. Laurent, G. Lekeux, A. A. Ukuwela, Z. Xiao, J.-B. Charlier, B. Bosman, M. Carnol, P. Motte, C. Damblon, M. Galleni and M. Hanikenne has been accepted for publication in the journal Plant Molecular Biology

  • December 2015

    Our paper entitled "Evaluation of Employing Poly-lysine Tags versus Poly-histidine Tags for Purification and Characterization of Recombinant Copper-Binding Proteins" by C. J. K. Wijekoon, A. A. Ukuwela, A. G. Wedd and Z. Xiao has been accepted for publication in the issue of the Journal of Inorganic Biochemistry dedicated to the memory of Prof. Graeme Hanson. Prof. Hanson was Prof. Wedd's second PhD student and graduated from La Trobe University in 1984.

  • November 2015

    Ben Spyrou has completed his Masters degree and will go on to a PhD with Dr. Paul Donnelly

    DingCyuan (Mobrick) Zeng has now completed the research section of his Masters degree and submitted his thesis

  • July 2015

    Laura Cortes won a Best Poster award at the 17th International Conference on Biological Inorganic Chemistry (ICBIC17) in Beijing, China for her poster was entitled "The Nature of the Cuprous and Ferrous Oxidase Active Sites in the Multi-Copper Oxidases CueO and Ceruloplasmin". The poster was so good that it was stolen off the display board at the end of the conference !

    At the conference, Doctor Xiao delivered his keynote lecture entitled "Probes for quantitative characterization of Cu(II) sites in proteins and peptides".

  • June 2015

    Saumya Udagedra has received the news that her PhD thesis has been accepted. Congratulations, Saumya !!

  • April 2015

    Doctor Xiao has been invited to deliver a keynote lecture at the 17th International Conference on Biological Inorganic Chemistry (ICBIC17) in Beijing, China from July 20-24, 2015. His title is "A set of robust fluorescent peptide probes for quantitative characterization of Cu(II) binding sites in proteins and peptides"

  • March 2015

    Saumya Udagedara has submitted her PhD thesis entitled "Molecular Characterisation of Copper Resistance and Transport Proteins in E. coli" for examination. This was achieved only three months after the birth of her son Desandu. Well done, Saumya !!

    Nineveh Yako has joined us to undertake her MS degree. Initially, she will work with Tessa Young on fluorescent probes.

  • February 2015

    Our paper entitled "The CopC Protein from Pseudomonas fluorescens SBW25 Features A Conserved Novel High Affinity Cu(II) Binding Site" by C. J. K. Wijekoon, T. R. Young, A. G. Wedd and Z. Xiao has now been published (Inorg. Chem. 2015, 54, 2950-59).

    In addition, our paper entitled "The Functional Roles of The Three Copper Sites Associated with The Methionine-Rich Insert in the Multicopper Oxidase CueO from E. coli" by L. Cortes Castrillon, A. G. Wedd and Z. Xiao has appeared on the Web (Metallomics, 2015, DOI: 10.1039/C5MT00001G).

  • January 2015

    Our paper entitled "A Set of Robust Fluorescent Peptide Probes That Quantify Cu(II) Binding Affinities in the Range Micromolar to Femtomolar" by T. R. Young, C. J. K. Wijekoon, B. Spyrou, P. S. Donnelly, A. G. Wedd and Z. Xiao has now been published (Metallomics, 2015, 7, 567-78)

  • December 2014

    Laura Cortes and Tessa Young were selected to speak at the RACI Student Inorganic Chemistry Symposium at La Trobe University. Laura's title was "Seven Copper sites in a Copper Enzyme Have Evolved to Control Copper Toxicity in E. coli" and Tessa's title was "Affinity of the Aβ Peptide for Cu(I) and Cu(II)". Tessa was awarded one of the prizes for best oral presentation.

    Laura, Tessa, Doctor Xiao and Professor Wedd attended the Seventh Asian Biological Inorganic Chemistry Conference on the Gold Coast, Queensland. Laura and Tessa presented posters on their work and were selected for short oral presentations in the 'Poster Slam' competition. Doctor Xiao made an oral presentation entitled "A Set of Sensitive Fluorescent Probes for Quantification of Cu(II) Binding Affinities in the Micromolar to Femtomolar Range". Professor Wedd presented a plenary lecture entitled "Copper at the Molecular Level: Roles in Health and Disease".

  • August 2014

    The Royal Society of Chemistry has announced publication of the book 'Binding, Transport and Storage of Metal Ions in Biological Cells', edited by Wolfgang Maret (Kings College London) and Anthony Wedd (The University of Melbourne). This book is structured around the periodic table and focuses on the control of metal ions in cells. There are 28 chapters covering individual metal ions (over 900 pages). They include essential ions (such as Ca, Fe, Zn, Cu, etc) and toxic ions (such as Cr, Cd, Hg, Pb, etc).

  • July 2014

    Jens Brose received the news that his PhD thesis was accepted. The referees were very complimentary. Congratulations, Jens !!

    Professor Wedd attended the Biometals 2014 Conference at Duke University in the Research Triangle of North Carolina, US. He presented a keynote lecture entitled "A Correlation between Copper Homeostasis and Sulfur Redox Chemistry?".

  • June 2014

    Professor Wedd visited the Centre for Metals in Biology at the University of Queensland. He delivered a lecture entitled "Intriguing Aspects of the Metabolism of Copper" at a one-day symposium in the Centre.

  • April 2014

    PhD student Tatsuya Kitagawa has returned to the Nagoya Institute of Technology in Japan. He was with us for 10 months, working on the intriguing protein Sumo-2. The work initiated with Dr Blaine Roberts (Florey Institute) who will continue the work here in Melbourne.

  • March 2014

    Our paper "Redox Sulfur Chemistry of the Copper Chaperone Atox1 is Regulated by the Enzyme Glutaredoxin 1, the Reduction Potential of the Glutathione Couple GSSG/2GSH and the Availability of Cu(I)" by C. M. Sze, Z. Shi, G. N. Khairallah, L. Feketeova, R. A. J. OHair, Z. Xiao, P. S. Donnelly and A.G. Wedd has now been published on the Web (Metallomics 2014, 6, MT-ART-01-2014-000020.R1) It also has been highlighted by the journal as one of its HOT articles.

    Our paper "An Integrated Study of the Affinities of the Abeta16 Peptide for Cu(I) and Cu(II): Implications for the Catalytic Production of Reactive Oxygen Species" by Tessa R. Young, Angie Kirchner, Anthony G Wedd and Zhiguang Xiao has now been published (Metallomics 2014, 6, 505-517). The journal chose it as one of its HOT articles

    Mobrick, Ashwinie and Tessa have all arrived. Unluckily, they are helping with our laboratory move from the fourth floor to the fifth floor of the Bio21 Research Insititute

  • January 2014

    Tessa Young will commence her PhD work in March 2014. She will initially extend her work on binding of copper and catalytic activity of domains of the amyloid precursor protein.

    Ashwinie Ukuwela (Bsc (Hons), University of Peradeniya, Sri Lanka) will also commence her PhD work in March 2014.

    Ding-Cyuan (Mobrick) Zeng (BS, National Taiwan University) will commence his MSc

  • March 2014

    Our paper "Redox Sulfur Chemistry of the Copper Chaperone Atox1 is Regulated by the Enzyme Glutaredoxin 1, the Reduction Potential of the Glutathione Couple GSSG/2GSH and the Availability of Cu(I)" by C. M. Sze, Z. Shi, G. N. Khairallah, L. Feketeova, R. A. J. OHair, Z. Xiao, P. S. Donnelly and A.G. Wedd has now been published on the Web (Metallomics 2014, 6, MT-ART-01-2014-000020.R1) It also has been highlighted by the journal as one of its HOT articles.

    Our paper "An Integrated Study of the Affinities of the Abeta16 Peptide for Cu(I) and Cu(II): Implications for the Catalytic Production of Reactive Oxygen Species" by Tessa R. Young, Angie Kirchner, Anthony G Wedd and Zhiguang Xiao has now been published (Metallomics 2014, 6, 505-517). The journal chose it as one of its HOT articles

    Mobrick, Ashwinie and Tessa have all arrived. Unluckily, they are helping with our laboratory move from the fourth floor to the fifth floor of the Bio21 Research Insititute

  • January 2014

    Tessa Young will commence her PhD work in March 2014. She will initially extend her work on binding of copper and catalytic activity of domains of the amyloid precursor protein.

    Ashwinie Ukuwela (Bsc (Hons), University of Peradeniya, Sri Lanka) will also commence her PhD work in March 2014.

    Ding-Cyuan (Mobrick) Zeng (BS, National Taiwan University) will commence his MSc in March 2014.

  • December 2013

    Doctor Zhiguang Xiao attended the Twelfth International Symposium on Applied Bioinorganic Chemistry (ISABC12) in Guangzhou, China on December 3rd – 6th, 2013. He presented a keynote lecture entitled "The Chemistry of Copper Ions Bound to the Amyloid Precursor Protein and to Abeta peptides Helps Define their Possible Roles in Alzheimers Disease".

    Jens Brose and Professor Wedd attended IC13, the Inorganic Chemistry Divisional Conference of the RACI in Brisbane on December 8-12, 2013. Jens took part in the Stranks Award Symposium, making both an oral and a poster presentation entitled "Redox Sulfur Chemistry in Copper Nutrition is Mediated by the Enzyme Grx1". Professor Wedd presented a lecture entitled "The Sting in the Tail !! Reaction Mechanism of CueO, a Multi-Copper Oxidase from Escherichia coli".

    In collaboration with Professor Wolfgang Maret, Kings College, London), Professor Wedd has edited a book entitled "Binding, Transport and Storage of Metal Ions in Biological Cells" (ISBN no. 978-1-84973-599-5). It features 28 chapters covering molecular aspects of ingress, transport, regulation and egress of both essential and non-essential (toxic) metal ions. It will be published in 2014 as part of the new Metallo-Biology Series of the Royal Society of Chemistry.

  • November 2013

    Tessa Young has achieved First Class Honours in her fourth year Honours course, with an average of >90 %. Congratulations, Tessa !!

    The group attended the Annual Students Symposium of the Inorganic Chemistry Group of the RACI (Victorian Branch) on Friday, November 29, 2013. Saumya Udagedara received an award for her oral presentation "Challenges in Expression and Characterisation of the Membrane Protein CopA - a Pump Essential for Copper Homeostasis in E. coli". In addition, Laura Cortes Castrillon received the prize for "Best Question".

    Our paper "Quantification of Copper Binding to Amyloid Precursor Protein Domain 2 and its Caenorhabditis elegans Ortholog. Implications for Biological Function" by S. L. Leong, T. R. Young, K. J. Barnham, A. G. Wedd, M. G. Hinds, Z. Xiao and R Cappai has been accepted for publication in Metallomics (MT-ART-09-2013-000258).

  • October 2013

    Professor Wedd visited the School of Chemistry and Physics at the University of Adelaide for research discussions. He presented a seminar entitled "The Affinity of the Abeta Peptide for Cu(I) and Cu(II): Implications for the Catalytic Production of Reactive Oxygen Species".

  • August 2013

    Ms Chathuri Wijekoon (Bsc (Hons), University of Peradeniya, Sri Lanka) has commenced a PhD degree with the group. She will be examining the chemistry of copper pumps and their partners.

  • July 2013

    Masters student Ben Spyrou has joined the group. He is interested in the binding of copper and iron to alpha-synuclein, the protein associated with Parkinsons disease.

    Professor Wedd attended the Fourth International Symposium on Metallomics held in Oviedo, Spain from July 8-11, 2013. He made a presentation entitled "Evaluation of Quantitative Probes for Weaker Cu(I) Binding Sites Completes a Set of Four Capable of Detecting Cu(I) Affinities from Nanomolar to Attomolar".

    Saumya Udagedara and Professor Wedd attended the Sixteenth International Conference on Biological Inorganic Chemistry in Grenoble, France from July 22-26, 2013. Saumya presented a poster entitled "PcoE, a metal sponge expressed to the periplasm of copper resistance E. coli. Implication of its function role in copper resistance". She also initiated a collaboration with Professor Christoph Fahrni (Georgia Institute of Technology) on chromophoric probes for copper. Professor Wedd presented a keynote lecture entitled "New Probes for Weaker Cu(I) Binding Sites Completes a Set of Four That Can Detect Affinities from Nanomolar to Attomolar".

  • June 2013

    PhD student Tatsuya Kitagawa has arrived to work with us for ten months. He is from the Nagoya Institute of Technology in Japan. He will work initially on the intriguing protein Sumo-2, which is appropriate as he is from Japan !!.

    Our paper "Interaction of Cisplatin and Analogue Pt(en)Cl2 with the Copper Metallo-Chaperone Atox1" by C. M. Sze, Z. Shi, G. N. Khairallah, L. Feketeová, R. A. J. O’Hair, Z. Xiao, P. S. Donnelly and A.G. Wedd has now been published (Metallomics 2013, 5, 956-964).

  • May 2013

    Our paper "Evaluation of Quantitative Probes for Weaker Cu(I) Binding Sites Completes a Set of Four Capable of Detecting Cu(I) Affinities from Nanomolar to Attomolar" has now been published (Metallomics 2013, 5, 501-513).

  • April 2013

    Saumya Udagedara has received support from the Bio21 Institute for attendance at the 16th International Conference on Biological Inorganic Chemistry in Grenoble in July.

    Our paper "Evaluation of Quantitative Probes for Weaker Cu(I) Binding Sites Completes a Set of Four Capable of Detecting Cu(I) Affinities from Nanomolar to Attomolar" is at the top of the list of most downloaded Advance Articles from the Metallomics website for April.

    Dr. Zhiguang Xiao presented a seminar entitled "Is Oxidative Stress in Neurodegenerative Diseases Linked to Copper Binding to the Disease Proteins?" to the School of Chemistry, University of Melbourne on April 23.

  • March 2013

    Laura Cortes Castrillon has arrived and started her PhD work. She will initially work with Franziska Boneberg and Dr Zhiguang Xiao to clone and express certain multi-copper oxidase enzymes.

    Angie Kirchner and Franziska Boneberg have arrived to carry out research projects that are part of the requirements of the Masters in Biochemistry and Chemistry at the Ludwig-Maximilians University of Munich, Germany. Angie is working with Tessa Young on identifying chromophoric probes for Cu(II). Franziska's work is described above.

    Sarah Buckley has decided to postpone her Masters work and to take a break.

    The following manuscript has been accepted for publication in Metallomics: "Evaluation of Quantitative Probes for Weaker Cu(I) Binding Sites Completes a Set of Four Capable of Detecting Cu(I) Affinities from Nanomolar to Attomolar" by Z. Xiao, L. Gottschlich, R. van der Meulen, S. R. Udagedara and A. G. Wedd.

  • February 2013

    Tessa Young has started her Honours work. She is working on defining the affinities of Abeta peptides for Cu(I) using new chromophoric probes developed in the laboratory by Dr. Zhiguang Xiao.

    Sarah Buckley has started her Masters project. She aims to define the affinities of the alpha-synuclein protein (associated with Parkinson's Disease) for copper to determine if it is able to act as a catalyst to produce toxic reactive oxygen species.

    A paper based on the work of Zhenyu Zhi has now appeared: Z. Shi, A. G. Wedd and S. L. Gras "Parallel In Vivo DNA Assembly by Recombination: Experimental Demonstration and Theoretical Approaches" PLoS ONE 2013,8(2): e56854. doi:10.1371/journal.pone.0056854.

  • December 2012

    Dr Zhiguang Xiao spoke at the Free Radical and Metal Biology Conference in Brisbane: "Quantification of Weak Cu(I) Binding Helps Understanding the Role of Copper in Neurodegenerative Diseases"

    Laura Cortes Castrillon will be starting her PhD work with us in February. Laura will be our first student ever from Columbia !! She has a background in synthetic and structural inorganic chemistry>

    Tessa Young has started work as a Summer Student. She will continue as an Honours Student in 2013. Good luck with it all, Tessa !

  • November 2012

    Professor Wedd attended the Sixth Asian Conference on Biological Inorganic Chemistry in Hong Kong and presented an invited paper entitled "Metallo-Oxidase Enzymes".

    The group's application for support for 2013-15 to the Australian Research Council was successful: "How does Redox Cycling Drive the Metabolism of the Essential Metals Iron and Copper?"

    Jens Brose spoke at the Inorganic Chemistry Symposium of the Victorian Branch of the Royal Australian Institute about "Glutaredoxin 1: A Redox Enzyme and Cu(I) Binding Protein?" He was awarded an 'Honourable Mention' as one of the three best oral presentations. David Hayne (Donnelly Group) also achieved this distinction.

  • October 2012

    Our research visitors Lisa Gottschlich and Renate van der Meulen have finished their time with us and returned home to Germany and Holland via, respectively, the Great Barrier Reef and Indonesia !! Their work has contributed to the manuscript "Evaluation of quantitative probes for weaker Cu(I) binding sites completes a set of four capable of detecting Cu(I) affinities from nano-molar to atto-molar" which will be submitted at the end of the year.

  • September 2012

    Our paper in the Hans Freeman Memorial Issue of the Journal of Inorganic Biochemistry has now appeared: M. Zimmermann, S. Udegadara, C. M. Sze, T. Ryan, Z. Xiao and A. G. Wedd, "PcoE, a metal sponge in the periplasm of copper resistant E. coli" J. Inorg. Biochem. 2012, 115, 186-197.

  • August 2012

    The following paper, designated as an Edge Article by the journal, has now been published: "The Challenges of Using Fluorescent Sensor CS1 to Track Intracellular Cu", Chemical Science, 2012, 3, 2748-2759. This was a collaboration with the White Group (Pathology) and the Donnelly Group (Chemistry) and showed that the chemical complexity of living cells can have diverse effects on the action of molecular probes designed to detect specific intracellular pools of copper. Dr Zhiguang Xiao contributed key thermodynamic and spectroscopic characterisation data.

    In addition, the following article has appeared: "Photochemical Oxidation of Water and Reduction of Polyoxometalate Anions at Interfaces of Water with Ionic Liquids or Diethylether" Proc. Natl. Acad. Sci. USA 2012, 109, 11552-11557. This was a collaboration with the Bond Group at Monash. The work showed that classic polyoxometalate cluster anions are robust catalysts for the photo-oxidation of water when irradiated in the presence of ionic liquids (liquid salts) in solution.

  • July 2012

    Jens Brose has been awarded a speaking slot for his poster paper at the Biometals 12 Conference: "Can Human Glutaredoxin (hGrx1) Act as Both a Thiol-disulfide Oxido-reductase Enzyme and a Cu(I) Binding Protein ?". Our former colleague Dr Lianyi Zhang (Centre for Oral Health, Melbourne) will also be speaking.

    Professor Wedd is also attending the Biometals 12 Conference in Brussels and will present an invited paper entitled "Metallo-Oxidase Enzymes".

  • June 2012

    Saumya Udagedara is returning to Sri Lanka for her marriage to Ashan Garusinghe who is an engineer. They will be coming back to Australia to commence married life.

    Jens Brose has left for a vacation at home in Germany. While there, he will visit colleagues at the University of Frankfurt and then go on to the Biometals 12 Conference in Brussels, Belgium. He will present a poster paper entitled "Can Human Glutaredoxin (hGrx1) Act as Both a Thiol-disulfide Oxido-reductase Enzyme and a Cu(I) Binding Protein ?".

  • May 2012

    Zhenyu Shi is celebrating receipt of the examiners reports for his PhD thesis: "Parallel DNA Assembly by Recombination". The research was carried out in collaboration with Dr Sally Gras (Chemical and Biomolecular Engineering).

    Lisa Gottschlich has arrived to carry out a research project that is part of the requirements of her biochemistry diploma course at the Johann-Wolfgang Goethe University in Frankfurt am Main, Germany.

    In addition, Renate van der Meulen has arrived for research associated with her Masters in Biomolecular sciences (specialization: Biological Chemistry) at the Free University of Amsterdam.

  • March 2012

    Gjoko Buncic is celebrating publication of his paper "Copper complexes of a novel non-innocent quadridentate ligand" in Chem. Commun 2012, 2570-2. It was selected to be the front cover for this issue of the journal.

  • February 2012

    Lee Xin Chong has received excellent examiners reports for her PhD thesis entitled "Molecular Characterization of Copper Tolerance and Resistance Proteins and Enzymes in Gram-Negative Bacteria". She has joined the Commonwealth Serum Laboratory (CSL) as a research scientist. This is Australia’s largest pharmaceutical company.

  • January 2012

    Gjoko Buncic has received excellent examiners reports for his PhD thesis entitled “Synthesis and Application of Molecular Probes for Biologically Important Metal Ions”. He has been appointed as a research scientist with Clarity Pharmaceuticals, a spin-off company with Dr Paul Donnelly.

    Dr Zhiguang Xiao and Professor Wedd attended the 2012 Conference of the International Society for Zinc Biology in Melbourne. Dr Xiao presented his lecture "The Art of Measuring Metal-Protein/peptide Affinities and A Case Study of Zinc Selectivity in Biology".

  • December 2011

    Professor Wedd attended the RACI Inorganic Chemistry Conference IC11 in Perth WA and presented a lecture entitled "Molecular Pathways of Copper Uptake and Elimination"

  • November 2011

    Lee Xin Chong represented our group at the RACI Inorganic Symposium at Monash University with her lecture entitled "The Copper Protection Enzyme CueO: How It Works".

  • October 2011

    Our former colleague Dr Karrera Djoko (now at the University of Queensland) has married Dr Robert Borthwick, who was also a colleague here at Bio21 Institute (with Professor Andrew Holmes).

  • September 2011

    Saumya Udagedara has successfully completed the probationary period of her PhD degree.

    Simon James has received news that his PhD thesis has been accepted: "Influence of Perturbed Copper Homeostasis in Protein Aggregation and Neurodegenerative Disease". His project was a collaboration with Professor Ashley Bush (Victorian Mental Health Institute).

  • August 2011

    Professor Wedd presented a lecture entitled "The Challenge of Using the Fluorescent Sensor CS1 to Track Intracellular Copper" at the Fifteenth International Conference on Biological Inorganic Chemistry (ICBIC15) in Vancouver, Canada.

    He also visited Universidad Nacional Autonoma de Mexico in Mexico City for research discussions with Professors Peter Kroneck and Martha E. Sosa-Torres of the Faculty of Chemistry. He presented a lecture entitled "How Does Biology Cope with Copper? It is Toxic but Essential".

  • July 2011

    Lee Xin Chong presented a lecture entitled "The Copper Enzyme CueO Detoxifies Excess Copper" at the East Coast Protein Meeting at Coffs Harbour, NSW.

  • June 2011

    Professor Wedd presented a lecture entitled "Metallo-Oxidase Enzymes" at the Symposium in Honour of Professor Hans C. Freeman at the University of Sydney. Professor Freeman was famous for solving the first structure of a copper protein, the electron carrier plastocyanin. He also was instrumental in supporting biological inorganic chemistry in Australia and in the advent of the Australian Synchrotron.

  • March 2011

    Dr Zhiguang Xiao represented the Group at the Bio21 Institute Seminar. He outlined the range of our work on copper transporting proteins, with an emphasis on the characterisation of CopK which binds both Cu(I) and Cu(II) cooperatively (work of Lee Xin Chong with structural collaborators Mark Hinds (WEHI) and Megan Maher (University of Sydney).

  • February, 2011

    Jens Brose has successfully completed the probationary period of his PhD degree.

    Sebastian Cramer (University of Applied Science, Giessen, Germany) has joined us for eight weeks to participate in a project with CSL to reduce sulfur contaminants from protein wastes.

    Professor Wedd has been appointed Series Editor of the new RSC Metallobiology Series, Royal Society of Chemistry.

  • November, 2010

    Gjoko Buncic received the award for Best Student Poster at the 39th International Conference on Coordination Chemistry in Adelaide. The poster was entitled “Water-soluble Bis(thiosemicarbazone) Ligands:Sensitive Probes and Metal Buffers for Zinc”.

    Professor Wedd received the Burrows Award and delivered his plenary lecture at the conference: "How Does Biology Cope with Copper? It is Toxic but Essential".

  • October 2010

    Lee Xin Chong and Professor Wedd attended the Copper 10 Conference at Alghero, Italy. Lee Xin presented a poster entitled “The Copper Protection Enzyme CueO: How It Works’ and Professor Wedd presented a plenary lecture entitled "Copper Tolerance and Resistance in Gram Negative Bacteria"

  • September, 2010

    Saumya Udagedara (Bsc (Hons), University of Peradeniya, Sri Lanka) has commenced a PhD degree with the group.

    Professor Wedd has received the Burrows Award for Inorganic Chemistry from the Royal Australian Chemical Institute. He will receive the Award at the 39th International Conference on Coordination Chemistry in Adelaide in November and deliver a plenary lecture.

  • July, 2010

    Lee Xin Chong received the award for Best Oral Presentation at the meeting of the Melbourne Protein Group at La Trobe University. Her talk was entitled "Reaction Mechanisms of the Multicopper Oxidase CueO from Escherichia coli Support a Functional Role as a Cuprous Oxidase"

  • April 2010

    Jens Brose (Diplom, University of Bielefeld, Germany) has commenced a PhD degree with the group. Together with Dr. Zhiguang Xiao, he attended a workshop on cell-free expression of membrane proteins at the University of Frankfurt, Germany, in January.

  • January 2010

    Dr Jingli Ji has received a Monash Research Fellowship to continue his independent research in the School of Chemistry, Monash University.

    Karrera Djoko will receive her PhD degree at the March graduation ceremony. She has been appointed to a research fellowship in the group of Professor Alistair McEwan at the University of Queensland.

  • October 2009

    The PhD thesis of Matthias Zimmermann has been accepted: Molecular Characterisation of Novel Copper and Zinc Transporters. He will receive his degree at the November graduation ceremony. He has joined the Commonwealth Serum Laboratory (CSL) as a research scientist.

  • May 2009

    Congratulation to Ryan Gilbret-Wilson who received the Deans Award for the top honours student in Chemistry in 2008.

    Karrera Djoko Phd Thesis has been accepted. The Examiners recommended that she be nominated for the Chancellors Prize for Excellence.

    Matthias Zimmermann has presented his phd defence seminar entitled "Copper and Zinc: How Nature Sort Them Out".

    Jens Brose (University of Bielefeld, Germany) and Sonja Schimo (Johann Wolfgang Goethe University, Frankfurt, Germany) has joined us for research work associated with their Diploma Degrees.

  • December 2008

    Congratulations to Matthias Zimmermann, who received a Stranks Oral Presentation Award at the 9th RACI Inorganic Chemistry Conference in Christchurch, New Zealand.

    Karrera Djoko has submitted her PhD thesis. She will be starting her post-doctoral research project with Prof. Alastair McEwan at the University of Queensland in the new year. We wish her all the best.

  • November 2008

    Ryan Gilbert-Wilson and Luke Morran have completed their Honours degrees. We congratulate them and wish them all the very best in their future endeavours.

    Congratulations to Karrera Djoko, who received a Young Scientist Oral Presentation Award at the 4th Asian Biological Inorganic Chemistry in Jeju Island, South Korea.

  • September 2008

    Emma Stevens has joined us as a Chemistry 399 research student. She will be working with Lee Xin Chong to study several CopK mutants from C. metallidurans.

  • August 2008

    We welcome Jiaxi Song, who has joined us for 4 weeks as a winter vacation research experience student. She will be working with Lee Xin Chong to study the copper binding protein CopK from C. metallidurans.

  • July 2008

    Sinth Jegaskanda has joined us for 3 weeks as a winter vacation research experience student. He will be working with Karrera Djoko to express multicopper oxidases from E. coli.

  • May 2008

    Zhenyu Shi has joined us as a PhD student. He will be working initially on the multicopper oxidases from E. coli and move on to investigate copper pumps from the same bacterium.

  • Apr 2008

    We welcome back Lee Xin Chong, who has recently returned as a PhD student. She will be continuing her Honours work on CopK protein from C. metallidurans. She will also investigate copper pumps from E. coli.

  • Feb 2008

    Ryan Gilbert-Wilson and Luke Moran have recently joined us as Honours students in chemistry. Ryan is making polyoxometalate complexes with Dr. Jingli Xie. Luke is co-supervised by Dr. Paul Donnelly and is working copper-specific sensors.

 
 
 

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